Intarcia Therapeutics \USA

Intarcia promised to revolutionize diabetes treatment with ITCA 650, an implantable osmotic pump the size of a matchstick that delivered continuous exenatide (a GLP-1 agonist) for 6-12 months. The value proposition was elegant: eliminate daily injections, improve medication adherence (a massive problem in diabetes where 50%+ of patients don't take meds as prescribed), and deliver superior glycemic control through steady-state drug delivery. For patients tired of needles and forgetting doses, this was freedom. For payers, it promised reduced complications and hospitalizations. The psychological hook was powerful—set it and forget it healthcare, like an IUD for diabetes.

SECTOR Health Care
PRODUCT TYPE Medical
TOTAL CASH BURNED $1.4B
FOUNDING YEAR 1997
END YEAR 2020

Discover the reason behind the shutdown and the market before & today

Failure Analysis

Failure Analysis

Intarcia died from a lethal combination of regulatory failure and capital exhaustion, rooted in a fundamental misalignment between their manufacturing capabilities and FDA expectations....

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Market Analysis

Market Analysis

The diabetes therapeutics market in 2024 is dominated by GLP-1 receptor agonists, which have become blockbuster drugs generating $50B+ annually. Weekly injectables (Ozempic, Mounjaro,...

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Startup Learnings

Startup Learnings

Manufacturing is Product in Regulated Industries: Intarcia treated manufacturing as a back-end detail to be outsourced, but for FDA-regulated combination products, your manufacturing process...

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Market Potential

Market Potential

The diabetes market remains enormous—537 million adults with diabetes globally, projected to reach 783 million by 2045. However, the specific opportunity for long-acting implantable...

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Difficulty

Difficulty

Rebuilding this today would be extraordinarily difficult. The core challenge isn't the technology—osmotic pump delivery systems are well-understood—but navigating the FDA regulatory gauntlet for...

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Scalability

Scalability

Scalability is severely constrained by the nature of the product. Each device requires: (1) a minor surgical procedure for insertion and removal by trained...

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Rebuild & monetization strategy: Resurrect the company

Pivot Concept

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A B2B2C platform that partners with Medicaid plans, correctional health systems, and nursing homes to deliver ultra-long-acting injectable medications (3-6 month duration) for chronic conditions via mobile nurse practitioners. Instead of building a new drug delivery device, leverage existing FDA-approved long-acting injectables (LAIs) for schizophrenia, HIV PrEP, contraception, and addiction treatment—medications where adherence failure has catastrophic consequences and where the target populations have structural barriers to pharmacy access. The business model is a per-member-per-month (PMPM) fee paid by institutions to guarantee medication adherence for high-risk populations. SteadyScript handles: (1) mobile nurse dispatch for in-home or in-facility injections, (2) medication procurement and cold chain logistics, (3) adherence tracking and reporting to payers, and (4) care coordination with primary care providers. The wedge is correctional health systems, where medication adherence is a major cost driver (inmates released without meds have 70% recidivism to emergency departments within 30 days). Unlike Intarcia, this doesn't require inventing new technology or navigating device approvals—it's a logistics and care delivery play using existing approved medications. The margin comes from reducing downstream costs (hospitalizations, incarcerations, disease progression) that payers are already paying for.

Suggested Technologies

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Salesforce Health Cloud for care coordinationTwilio for patient communication and appointment remindersModMed or athenahealth EHR integrationRoute optimization software like OptimoRoute for nurse dispatchCold chain IoT sensors like Sensitech for medication trackingStripe for billing and payer invoicing

Execution Plan

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Phase 1

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Partner with one county jail system or state Medicaid plan to pilot with 100 patients on long-acting injectable antipsychotics or buprenorphine for opioid use disorder—medications with clear ROI for payers due to reduced hospitalization and recidivism.

Phase 2

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Hire 2-3 nurse practitioners and equip them with mobile medication kits, scheduling software, and EHR access. Build a simple dispatch system to route nurses to patients based on injection schedules.

Phase 3

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Negotiate wholesale pricing with drug manufacturers for LAI medications and establish cold chain logistics with a specialty pharmacy partner to handle procurement and storage.

Phase 4

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Track adherence rates, healthcare utilization (ER visits, hospitalizations), and cost savings over 6 months. Build a dashboard for payers showing real-time adherence and outcomes data.

Phase 5

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Iterate on nurse workflows, patient communication protocols, and payer reporting to prove unit economics: cost per injection delivered vs. cost savings from avoided acute care events.

Monetization Strategy

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Per-member-per-month (PMPM) subscription fee paid by Medicaid MCOs, correctional health systems, or nursing homes. Pricing is $200-300 PMPM depending on medication type and visit frequency (monthly for buprenorphine, quarterly for antipsychotics). Revenue is recurring and predictable. For a panel of 1,000 members at $250 PMPM, that's $3M annual revenue. Gross margins are 40-50% after nurse labor, medication costs, and logistics. The business scales by adding more payers and geographies, not by inventing new products. Optionally, negotiate risk-sharing agreements where SteadyScript gets a percentage of savings from reduced hospitalizations or incarcerations, creating upside beyond the PMPM fee. This model works because payers are already spending $500-1,500 PMPM on these high-risk members through acute care—paying $250 PMPM for adherence is a bargain if it avoids one hospitalization per year.

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